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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Pregnancy-associated plasma protein A ： ウィキペディア英語版 Pregnancy-associated plasma protein A Pappalysin-1 also known as pregnancy-associated plasma protein A is a protein that in humans is encoded by the PAPPA gene. Pappalysin-1 is used in screening tests for Down syndrome.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5069 )〕 == Function == This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes).〔 For example, low PAPPA may be seen in prenatal screening for Down syndrome.〔 Low levels may alternatively predict issues with the placenta, resulting in adverse complications such as intrauterine growth restriction, preeclampsia, placental abruption, premature birth, or fetal death. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Pregnancy-associated plasma protein A」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.